When the body attacks itself, the problem is escalated through a series of ailments that are difficult to manage and handle. The nature of autoimmune disease has been alarming in the medical community because of the difficulty in its treatment and the apparent toll that it would have on the body. People need to realize that the potential threat autoimmune disease would have on the person can be life-threatening, so it is important to look into the potential technologies that have been researched in order to solve this conundrum. The essay writer definition of the microbiome used for treating inflammatory arthritis is one that reduces inflammation through a combined effort of metabolites that would improve the overall condition of the physiology of the person.
Microbiome manipulation is a cutting-edge technology that would focus on the utilization of small microorganisms to carry out a function that is needed. Nayak and Turnbaugh (2016) published the opinion on how microbiome manipulation, or the changing of the bacterial composition of a given person in a given part of his or her body would have health benefits. This argument would point toward the emerging field of how each bacterium would contribute to a more meaningful outcome in the recovery or the mitigation of an illness that a person would have.
The focus of this discussion would look into managing inflammatory arthritis, or one kind, rheumatoid arthritis. The initial point of view would be to examine the microbiome involved and its relationship with identifying triggers to the cause of rheumatoid arthritis. Next, an approach would be taken to address treatments involving the colonization with probiotics so that possible health improvements may be noted. These concerns would then be presented through the various challenges that might exist, especially regarding the cost and the efficacy of the approach. These insights will then be analyzed with the contention of how the movement toward improving technologies would be vital in the presentation of success, especially in mitigating the harsh reality of autoimmune diseases.
Inflammatory Arthritis: Impacts on the Patient and Microbiome Assessment
Jethwa and Abraham (2017) noted the inherent problem that patients with rheumatoid arthritis face, bad bacteria that exist in their gut, which would then lead to the worsening or the actual pathogenesis of the disease. Joint inflammation and disease may be sourced by the bacteria promoting inflammation, which, though not the cause, may be the trigger. Such bacteria would involve the Yersinia enterocolitica, which has been discovered in 1993 to be an inducer of arthritis. The danger of having the microbiome present in such quantity would be highly deleterious to the individual, especially in the resulting outcome that would advance the arthritis. Bacteria indeed can be troublesome for the individual. The reality that patients face with rheumatoid arthritis involves the overlap of bacteria presence and the disease, which would call for an investigation of how microbiomes can contribute to the prevalence of the disease.
Probiotic Therapy as a Means of Improving Patient Welfare
If the presence of microbiomes can result in the development of the disease, it is also possible for some microorganisms to actually stop or mitigate the effects of the disease. Probiotic therapy has been historically noted to invite good bacteria into humans because of their role as supportive to the functions of the people. Probiotics have been recognized for nearly a century because of this mechanism, and their relevance in the field of research and application through the food industry (Azizpour, Bahrambeygi, & Mahmoodpour, 2009). Toh, Anzela, Tang, and Licciardi (2012) also noted how probiotic therapy would be useful in combating allergic diseases, which would involve inflammatory responses being reduced. This is the kind of approach that would help in the prolonging of people’s lives and the potential for such change is noted with the proactive lens considered.
Now, how would this work in the perspective of rheumatoid arthritis? A lot of studies have been conducted, actually, regarding the use of probiotics, or the microbiome manipulation through introduction of good bacteria, for inflammatory diseases such as rheumatoid arthritis. For instance, the study of de los Angeles Pineda et al. (2011) noted how there was a functional improvement in the group that had the probiotic therapy. Maia, Levi, do Prado, dos Santos Santinoni, and Marcicano (2019) studied the impact of probiotics on serum inflammatory markers, the major indication of rheumatoid arthritis, and they found out that there is a positive change in systemic inflammatory biomarkers with the actual reduction of tumor necrosis factor-alpha and C-reactive protein, which would modulate the overall inflammatory process. This means that the probiotics, after extensive examination from multiple studies via meta-analysis, would be a good sign regarding how inflammation can be significantly controlled.
For rheumatoid arthritis specifically, Mohammed et al. (2017) note that there has been a lowered effect of inflammatory cytokines, which point toward the positive impact of the probiotic therapy, which would then hold a proactive improvement in the well-being of the patients involved. Zamani et al. (2016) noted that there is a statistically-significant improvement in the patients who received probiotic treatment, and this kind of insight would be hopeful about the potential that probiotics would have in terms of inflammatory response mechanisms and reduction of symptoms. An article at Everday Health (2017) noted that probiotics would be useful in improving overall gut health, which would show the inherent promise for effective probiotic treatment, and the findings have been important in terms of improving lifestyle health.
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Challenges to the Treatment
One important challenge to the treatment is really the amount of studies that conclude that the probiotics would hold significant impact on patient outcomes: the trouble is in the notion of circumstance. While the study by de los Angeles Pineda et al. (2011) noted positive results, statistical significance was achieved, which would make the test circumstance-based. Another aspect by Mohammed et al. (2017) is that they need more studies to prove that probiotic therapy is indeed helpful and conclusive.
The studies that have been provided would show that not all probiotic therapies are distinctly effective and that the outcomes would have to depend on various factors. Probiotic therapy has been noted to have positive outcomes, but the statistical values need to be improved in order to show due emphasis on the nature and the validity of the treatment protocols, especially in the perspective of promoting effective outcomes that are designed around improving patient welfare.
The challenges are quite evident in how we should look at how those little critters can help us heal. That is the reality that we should overcome and the contention that would be done should be aligned with those values. Probiotic therapy is still in the works when it comes to actual treatment, because the evidence that exists is circumstantial. Hence, there should be much done regarding how probiotics can help people with their problems. Malviya (2020) wrote that rheumatoid arthritis can be prevented through a healthy diet, and these considerations must also be supported through proper strategies that would employ beefing up our immune system and living a positive life in general, since mindset is really everything when it comes to the condition of how we live. The challenges are bountiful but we should look at the potential hopes when it comes to really helping our body handle the pains caused by bad bacteria.
Hopes
Probiotic treatment has been present in society, but its medical foundation needs to be strengthened. There is hope to the potential success of probiotic treatment because of the studies slowly integrating more and more positive outcomes that would benefit people in the long run. In fact, an article published in 2019 by Science Daily noted that probiotics has been known to treat a condition in children, which goes to show that the treatment has promise. Another insight from Columbia University presents how a designer probiotic treatment can be used for cancer therapy. The article, published just a week ago on February 10, 2020 examined how probiotics can be used to treat cancer, one of the major problems that have high mortality rates (Columbia, 2020). The hope for probiotic is there, particularly in how probiotics can work to combat deadly diseases. Another insight drawn from Meissner (2020) noted that probiotics have shown promise, but they need to be studied in depth. While this hope is noted, the probiotics must be studied effectively.
For the case of rheumatoid arthritis, Rhodes (2020) published a news article on how probiotics, through diet, can have anti-inflammatory effects. The Mediterranean diet, as noted by the author, has been known to reduce inflammation among patients, and this is due to the support of probiotics found in the diet. Probiotic therapy is not limited to clinical procedure, but also a measure of lifestyle adjustment. Another article by Upham (2019) discussed that the anti-inflammatory diet can improve the rheumatoid arthritis symptoms, which would be an important hope for the better in terms of the symptoms of the disease.
Probiotic therapy is a holistic treatment that would require extensive study, but the promise is indeed noted through the insights drawn from these studies. What needs to be done is to really perform more research and engage more individuals in the probiotic therapy measures so that there is a positive insight that can be drawn from the treatment that would exist in the process.
Conclusion
The use of microbiome support is a major potential in the field of improved clinical measure. The idea that microorganisms who normally would be disease-causers can actually be disease-curers is a dream that would come true in the near future; all people would have to do is look for the right blend and provide the right conditions for such measure. Probiotic therapy has been known by some studies to reduce inflammation, which would improve the welfare of patients with rheumatoid arthritis. The studies revealed that positive response is there, but there is a notion of significance.
This brought about the challenge of probiotic therapy as a standard treatment that would be implemented. Not many studies have conclusive outcomes, which would put probiotic therapy in the field of circumstantial measures. The potential of probiotics is there but the reality is not as conclusive. In the field of medicine, conclusive results are vital for the success of the patient’s recovery. Despite the little studies, there are insights and breakthroughs that have been presented regarding the hope of probiotic therapy. Such therapy is known to be a mover of change in terms of promoting patient health, with the noted inflammatory reduction effects. What needs to be done is to enhance these aspects by promoting more studies and more insight.
References
Azizpour, K., Bahrambeygi, S., & Mahmoodpour, S. (2009). History and basic of probiotics. Research Journal of Biological Sciences, 4(4), 409-426.
Columbia. (2020). Designer probiotic treatment for cancer immunotherapy. Retrieved from https://www.newswise.com/articles/designer-probiotic-treatment-for-cancer-immunotherapy
de los Angeles Pineda, M., Thompson, S. F., Summers, K., de Leon, F., Pope, J., & Reid, G. (2011). A randomized, double-blinded, placebo-controlled pilot study of probiotics in active rheumatoid arthritis. Medical science monitor: international medical journal of experimental and clinical research, 17(6), CR347.
Everyday Health. (2017). Probiotics for rheumatoid arthritis: pros and cons. Retrieved from https://www.everydayhealth.com/rheumatoid-arthritis/treatment/probiotics-rheumatoid-arthritis-pros-cons/
Jankovic, I., Sybesma, W., Phothirath, P., Ananta, E., & Mercenier, A. (2010). Application of probiotics in food products—challenges and new approaches. Current Opinion in Biotechnology, 21(2), 175-181.
Jethwa, H., & Abraham, S. (2017). The evidence for microbiome manipulation in inflammatory arthritis. Rheumatology, 56(9), 1452-1460.
Maia, L. P., Levi, Y. L. D. A. S., do Prado, R. L., dos Santos Santinoni, C., & Marsicano, J. A. (2019). Effects of probiotic therapy on serum inflammatory markers: A systematic review and meta-analysis. Journal of functional foods, 54, 466-478.
Malviya, S. (2020). Can rheumatoid arthritis be prevented? Tips for prevention. Doctor NDTV. Retrieved from https://doctor.ndtv.com/bones-joints/can-ra-be-prevented-tips-to-prevent-ra-2171989
Meissner, C. (2020). Are probiotics ready for prime time? AAP News. Retrieved from https://www.aappublications.org/news/2020/01/03/idsnapshot010320
Mohammed, A. T., Khattab, M., Ahmed, A. M., Turk, T., Sakr, N., Khalil, A. M., … & Huy, N. T. (2017). The therapeutic effect of probiotics on rheumatoid arthritis: a systematic review and meta-analysis of randomized control trials. Clinical rheumatology, 36(12), 2697-2707.
Nayak, R. R., & Turnbaugh, P. J. (2016). Mirror, mirror on the wall: which microbiomes will help heal them all?. BMC medicine, 14(1), 72.
Rhodes, C. (2020). Can rheumatoid arthritis be modified with an anti-inflammatory diet? Practical Pain Management. Retrieved from https://www.practicalpainmanagement.com/resources/news-and-research/can-rheumatoid-arthritis-be-modified-anti-inflammatory-diet
Science Daily. (2019). Probioetic may help treat colic in infants. https://www.sciencedaily.com/releases/2019/12/191204145840.htm
Toh, Z. Q., Anzela, A., Tang, M. L., & Licciardi, P. V. (2012). Probiotic therapy as a novel approach for allergic disease. Frontiers in pharmacology, 3, 171.
Upham, B. (2019). An anti-inflammatory diet can improve RA symptoms in just two weeks, new research suggests. Retrieved from https://www.everydayhealth.com/rheumatoid-arthritis/an-anti-inflammatory-diet-can-improve-ra-symptoms-in-just-two-weeks-new-research-suggests/
Zamani, B., Golkar, H. R., Farshbaf, S., Emadi‐Baygi, M., Tajabadi‐Ebrahimi, M., Jafari, P., … & Asemi, Z. (2016). Clinical and metabolic response to probiotic supplementation in patients with rheumatoid arthritis: a randomized, double‐blind, placebo‐controlled trial. International journal of rheumatic diseases, 19(9), 869-879.
